Helene D. Gayle discusses her work as the person responsible for providing overall leadership, management and direction to one of the world's premier international relief and development organizations, CARE. With programs in some 70 countries, CARE helps people in poor communities expand the control they have over their own lives to advance positive, enduring social change. CARE helps millions of people recover from natural disasters and other acute emergencies, prevent the spread of HIV/AIDS, and gain access to healthcare, nutrition, education, safe water, and improved sanitation. Dr. Gayle also served as the AIDS coordinator and chief of the HIV/AIDS division for the US Agency for International Development (USAID). She has served as a health consultant to international agencies including the World Health Organization (WHO), UNICEF, the World Bank and UNAIDS, and has worked extensively in Africa, Asia, and the Americas. She also served as the Director of CDC's Washington Office. Prior to assuming her current position, she was the director of the HIV, TB and reproductive health program for the Bill and Melinda Gates Foundation. Dr. Gayle has published numerous articles on public health, especially related to HIV/AIDS and has received many awards for her scientific and public health contributions. She attained the rank of Rear Admiral (Assistant Surgeon General) in the US Public Health Service. She is also on the boards of the Institute of Medicine and the Council on Foreign Relations.